Systematic Review and Meta-Analysis of SERPINE1 4G/5G Insertion/Deletion Variant With Circulating Lipid Levels.

ABSTRACT:

Background

Recent studies have shown that the 4G/5G insertion/deletion variant of SERPINE1 (rs1799889) is closely linked to coronary artery disease (CAD). This study aims to clarify the effects of the rs1799889 variant on lipid levels and to insight into the mechanisms underlying the rs1799889 variant and CAD.

Methods and results

By searching PubMed and the Cochrane databases for studies published before 31 October 2021, 40 studies conducted on a total of 13,117 subjects were included for the analysis. The consistent findings for the effects of the 5G allele of rs1799889 variant on lipid metabolism were the significantly decreased triglycerides (TG) [standardized mean difference (SMD) = -0.12, 95% CI = -0.21 to 0.03, P = 0.01], total cholesterol (TC) (SMD = -0.

SUBMITTER: Luo Z 

PROVIDER: S-EPMC9260103 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature