Risk of Second Primary Neoplasms of the Central Nervous System.

ABSTRACT:

Purpose

Second primary (SP) neoplasms of the central nervous system (CNS) among cancer survivors are devastating but poorly understood processes. The absolute risk, or true incidence, of developing an SP CNS tumor among cancer survivors is not well characterized.

Methods and materials

Patients diagnosed with cancer between 1975 and 2016 were queried using the Surveillance, Epidemiology, and End Results Program. Cumulative incidence rates (CIRs) were estimated using competitive risk analysis. The effects of covariates were assessed using multivariate competitive risk regression.

Results

More than 3.8 million patient records were extracted. The absolute risk of developing an SP CNS neoplasm at 25 years was highest among long-term survivors of CNS cancers (CIR, 6.6%). Cr

SUBMITTER: Liu EK 

PROVIDER: S-EPMC9260125 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature