Investigating Fractal Analysis as a Diagnostic Tool That Probes the Connectivity of Hippocampal Neurons.

ABSTRACT: Many of nature's fractal objects benefit from the favorable functionality that results from their pattern repetition at multiple scales. Our recent research focused on the importance of fractal scaling in establishing connectivity between neurons. Fractal dimension D _A of the neuron arbors was shown to relate to the optimization of competing functional constraints-the ability of dendrites to connect to other neurons versus the costs associated with building the dendrites. Here, we consider whether pathological states of neurons might affect this fractal optimization and if changes in D _A might therefore be used as a diagnostic tool in parallel with traditional measures like Sholl analyses. We use confocal microscopy to obtain images of CA1

SUBMITTER: Rowland C 

PROVIDER: S-EPMC9260144 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature