Association of outpatient use of renin-angiotensin-aldosterone system blockers on outcomes of acute respiratory illness during the COVID-19 pandemic: a cohort study.

ABSTRACT:

Objectives

Evaluate the associations between patients taking ACE inhibitors and angiotensin receptor blockers (ARBs) and their clinical outcomes after an acute viral respiratory illness (AVRI) due to COVID-19.

Design

Retrospective cohort.

Setting

The USA; 2017-2018 influenza season, 2018-2019 influenza season, and 2019-2020 influenza/COVID-19 season.

Participants

People with hypertension (HTN) taking an ACEi, ARB or other HTN medications, and experiencing AVRI.

Main outcome measures

Change in hospital admission, intensive care unit (ICU) or coronary care unit (CCU), acute respiratory distress (ARD), ARD syndrome (ARDS) and all-cause mortality, comparing COVID-19 to pre-COVID-19 influenza seasons.

Results

The cohort included 1 059 474 episodes of A

SUBMITTER: Jeffery MM 

PROVIDER: S-EPMC9260198 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature