Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications.

ABSTRACT: Vitamin D deficiency has been associated with the risk of multiple sclerosis, disease activity and progression. Results from in vitro experiments, animal models and analysis of human samples from randomized controlled trials provide comprehensive data illustrating the pleiotropic actions of Vitamin D on the immune system. They globally result in immunomodulation by decreasing differentiation of effector T and B cells while promoting regulatory subsets. Vitamin D also modulates innate immune cells such as macrophages, monocytes and dendritic cells, and acts at the level of the blood-brain barrier reducing immune cell trafficking. Vitamin D exerts additional activity within the central nervous system reducing microglial and astrocytic activation. The immunomodulatory role of Vitamin D

SUBMITTER: Galoppin M 

PROVIDER: S-EPMC9260308 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature