Impact of Aging on Urinary Natriuretic Peptides in Nocturia and Nocturnal Polyuria.

ABSTRACT:

Purpose

The pathophysiology of nocturia and nocturnal polyuria (NP), conditions that become more prevalent with aging, may in part be explained by changes in hormones involved in water homeostasis. The purpose of this study was to analyze the impact of aging on urinary natriuretic peptides in nocturia and NP.

Methods

Patients aged ≥18 years completed 24-hour bladder diaries for assessment of nocturia and NP. They were divided into subgroups of ≥65 years old and <65 years old. Urine samples were collected and analyzed for natriuretic peptide (NT-proANP, NT-proBNP, and NT-proCNP) levels. Peptide levels were compared between patients with and without nocturia/NP and within age subgroups; correlation to the NP index (NPi) was determined.

Results

Compared to patients witho

SUBMITTER: Khosla L 

PROVIDER: S-EPMC9260326 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature