Evaluation of Th17 and Treg cytokines in patients with unexplained recurrent pregnancy loss.

ABSTRACT:

Background and aim

The Th17/Treg balance in peripheral blood and reproductive tissues may have a role in the etiology of unexplained recurrent pregnancy loss (URPL). In this study, we evaluated the major cytokine of Treg cells transforming growth factor-beta (TGF-β), and their specific transcription factor Forkhead box P3 (FOXP3), as well as the most highlighted cytokine of Th17 cells (interleukin [IL]-17A) in both URPL patients and healthy women.

Methods

Samples were extracted from the peripheral blood, endocervix, endometrium, and vagina of 14 patients with URPL and 12 normal non-pregnant women as a control (normal) group. Quantitative reverse transcription polymerase chain reaction was used to determine gene expression. Enzyme-linked immunosorbent assay was used to determ

SUBMITTER: Farshchi M 

PROVIDER: S-EPMC9260344 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature