Goal-Directed Fluid Therapy Based on Pulse-Pressure Variation Compared with Standard Fluid Therapy in Patients Undergoing Complex Spine Surgery: A Randomized Controlled Trial.

ABSTRACT:

Study design

Prospective, randomized, controlled study.

Purpose

To determine whether the use of goal-directed fluid therapy (GDT) guided by pulse-pressure variation (PPV) and fluid management protocol can reduce intraoperative hypotension, blood transfusion requirements, and postoperative complications in adults undergoing complex spine surgery.

Overview of literature

Complex spine surgeries involve a significant risk of blood loss and intraoperative hypotension. Previous studies showed that GDT reduces intraoperative hypotension and postoperative complications in these surgery types; however, limited information exists about GDT guided by PPV.

Methods

Sixty adults (18-70 years) patients undergoing complex spine surgeries at Siriraj Hospital, Mahidol University

SUBMITTER: Wongtangman K 

PROVIDER: S-EPMC9260406 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature