Dataset Information

Infestation, histology, and molecular confirmation of Sarcoptes scabiei in an Andean porcupine (Coendou quichua) from the Central Andes of Colombia.

ABSTRACT: Sarcoptic mange is a highly contagious, worldwide disease that affects the skin of mammals, including humans. It is caused by the mite Sarcoptes scabiei, however, the information available in wild mammal populations in the world, and particularly in Colombia is limited. Here, we document a new case of sarcoptic mange in an Andean porcupine (Coendou quichua) from the Andean region of Colombia. We morphologically and molecularly confirmed the mite as S. scabiei and documented the histopathology associated with scabies, and show the different stages of the life cycle of S. scabiei from the Andean porcupine skin samples. Our review of reports of additional cases of scabies in wild mammal species in South America showed 15 species, mostly carnivores, artiodactyls, and rodents. Considering the limited information in Colombia, it is urgent to evaluate the risk of this condition on mammals which would contribute to the epidemiological knowledge and the potential implications of sarcoptic mange in the ecology and conservation of wild mammals in the country.

SUBMITTER: Busi A

PROVIDER: S-EPMC9260439 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Infestation, histology, and molecular confirmation of Sarcoptes scabiei in an Andean porcupine (Coendou quichua) from the Central Andes of Colombia.

Busi Ana A Ospina-Pérez Erika Mayerly EM Rodríguez-Hurtado Caterine C Mejía-Fontecha Ingrith Y IY Ossa-López Paula A PA Rivera-Páez Fredy A FA Ramírez-Chaves Héctor E HE

International journal for parasitology. Parasites and wildlife 20220702

Sarcoptic mange is a highly contagious, worldwide disease that affects the skin of mammals, including humans. It is caused by the mite Sarcoptes scabiei, however, the information available in wild mammal populations in the world, and particularly in Colombia is limited. Here, we document a new case of sarcoptic mange in an Andean porcupine (Coendou quichua) from the Andean region of Colombia. We morphologically and molecularly confirmed the mite as S. scabiei and documented ...[more]

PMID: 35814637

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Project description:The burrowing mite Sarcoptes scabiei causes scabies in humans or mange in animals. It infests a wide range of mammalian species including livestock, companion animals, wild animals, and humans. Differential diagnosis of Sarcoptes varieties is key for epidemiological studies and for formulation of an eradication program. Host-parasite interaction at the systemic level is very important to understand the pathogenicity of the mite. This communication deals with the preliminary report on the genetic characterization of S. scabiei from India. Moreover, the effect of S. scabiei infestation on host physiology with special emphasis on serum biochemical parameters, lipid profile, oxidant/antioxidant balance, stress parameters, and immune responses were evaluated in a porcine model. Cytochrome C oxidase 1 and voltage-sensitive sodium channel based phylogenetic study could distinguish human and animals isolates but could not distinguish host or geographical specific isolates belonging to animal origin. An absence of host-specific cluster among animal isolates argues against the hypothesis of delineating S. scabiei as per host origin. Elevated levels of markers of liver function such as albumin, AST, ALT, ALP, and LDH in infested animals indicated impaired liver function in infested animals. S. scabiei infestation induced atherogenic dyslipidemia indicated by elevated levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides, and a decreased level of high-density lipoprotein cholesterol. Oxidative stress in infested animals was indicated by a high level of nitric oxide and serum MDA as oxidative stress markers and low antioxidant capacity. S. scabiei triggered stress response and elevated levels of serum cortisol and heat shock proteins were recorded in infested animals. S. scabiei infestation increased the serum concentration of immunoglobulins and was associated with up-regulation of IL-2, IFN-γ, IL-1β, and IL-4 indicating both Th1 and Th2 response. The results of the study will be helpful for a better understanding of host-parasite interaction at the systemic level in crusted scabies in pigs.

Dataset Information

Infestation, histology, and molecular confirmation of Sarcoptes scabiei in an Andean porcupine (Coendou quichua) from the Central Andes of Colombia.

Publications

Infestation, histology, and molecular confirmation of <i>Sarcoptes scabiei</i> in an Andean porcupine (<i>Coendou quichua</i>) from the Central Andes of Colombia.

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