Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children.

ABSTRACT:

Importance

Prenatal exposures to endocrine-disrupting chemicals (EDCs) may increase the risk for liver injury in children; however, human evidence is scarce, and previous studies have not considered potential EDC-mixture effects. Furthermore, the association between prenatal EDC exposure and hepatocellular apoptosis in children has not been studied previously.

Objective

To investigate associations of prenatal exposure to EDC mixtures with liver injury risk and hepatocellular apoptosis in childhood.

Design, setting, and participants

This prospective cohort study used data collected from April 1, 2003, to February 26, 2016, from mother-child pairs from the Human Early-Life Exposome project, a collaborative network of 6 ongoing, population-based prospective birth cohort

SUBMITTER: Midya V 

PROVIDER: S-EPMC9260485 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature