Gold nanoparticles decorated with ovalbumin-derived epitopes: effect of shape and size on T-cell immune responses.

ABSTRACT: Gold nanoparticles (GNPs) can be manufactured in various shapes, and their size is programmable, which permits the study of the effects imposed by these parameters on biological processes. However, there is currently no clear evidence that a certain shape or size is beneficial. To address this issue, we have utilised GNPs and gold nanorods (GNRs) functionalised with model epitopes derived from chicken ovalbumin (OVA_257-264 and OVA_323-339). By using two distinct epitopes, it was possible to draw conclusions regarding the impact of nanoparticle shape and size on different aspects of the immune response. Our findings indicate that the peptide amphiphile-coated GNPs and GNRs are a safe and versatile epitope-presenting system. Smaller GNPs (∼15 nm in diameter) induce signi

SUBMITTER: Egorova EA 

PROVIDER: S-EPMC9260517 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature