Genome-wide Meta-analysis Reveals New Gene Signatures and Potential Drug Targets of Hypertension.

ABSTRACT: The prevalence of hypertension reported around the world is increasing and is an important public health challenge. This study was designed to explore the disease's genetic variations and to identify new hypertension-related genes and target proteins. We analyzed 22 publicly available Affymetrix cDNA datasets of hypertension using an integrated system-level framework involving differential expression genetic (DEG) analysis, data mining, gene enrichment, protein-protein interaction, microRNA analysis, toxicogenomics, gene regulation, molecular docking, and simulation studies. We found potential DEGs after screening out the extracellular proteins. We studied the functional role of seven shortlisted DEGs (ADM, EDN1, ANGPTL4, NFIL3, MSR1, CEBPD, and USP8) in hypertension after disease gene cur

SUBMITTER: Ali F 

PROVIDER: S-EPMC9260904 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature