Design of a Sensitive Fluorescent Zn-Based Metal-Organic Framework Sensor for Cimetidine Monitoring in Biological and Pharmaceutical Samples.

ABSTRACT: A new highly fluorescent zinc-organic framework [Zn₂(btca)(DMSO)₂]_n (Zn-MOF) was prepared via in situ ligand formation by the solvothermal reaction of Zn(NO₃)₂·6H₂O and pyromellitic dianhydride (PMDA) in DMSO solvent. During the solvothermal reaction, PMDA was gradually hydrolyzed to a pyromellitic acid, 1,2,4,5-benzene tetracarboxylic acid (H₄btca), to provide a tetracarboxylic acid as a linker in the reaction medium. Single-crystal X-ray diffraction analysis exhibits a 3D porous structure with open tetragonal channels running along the crystallographic c-axis. The Zn-MOF was explored as an on-mode fluorescent sensor for tracing cimetidine in biological fluids and pharmaceutical samples in th

SUBMITTER: Afravi Z 

PROVIDER: S-EPMC9260946 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature