Antibiotic exposure prevents acquisition of beneficial metabolic functions in the preterm infant gut microbiome.

ABSTRACT:

Background

Aberrations in the preterm microbiome following antibiotic therapy have been reported in previous studies. The objective of this study was to probe potential underlying mechanisms between this observation and susceptibility to adverse prematurity-related outcomes.

Results

Metagenomic shotgun sequencing was performed on 133 stool and 253 skin samples collected at 1 and 3 weeks of age from 68 infants born at <36 weeks postmenstrual age and birth weight <2000 g. After accounting for gestational age and maternal antibiotics, the distribution of organisms in all samples and the corresponding metabolic pathway abundance were compared between infants exposed to postnatal antibiotics and antibiotics-naïve infants. In antibiotic-naïve infants, gestational and postnatal age

SUBMITTER: Xu Y 

PROVIDER: S-EPMC9260971 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature