Associations of thiazide use with skin cancers: a systematic review and meta-analysis.

ABSTRACT:

Background

Previous findings on the associations of thiazide use with skin cancers were conflicting. This study aimed to examine the associations of individual thiazide use with skin cancer risk, differentiated by subtypes of skin cancers, geographic regions, and cumulative doses of individual thiazides.

Methods

We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials for relevant studies on January 5, 2022, scanned the references of included studies, and consulted experts. We included case-control and cohort studies or randomized trials reporting the associations of individual thiazide or thiazide-like diuretics use with skin cancers. Non-melanoma skin cancer (NMSC) and melanoma were analysed separately. A random-effects model meta-analysis was conduct

SUBMITTER: Shao SC 

PROVIDER: S-EPMC9260996 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature