Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia.

ABSTRACT: Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices at an early age of onset. The disorder shows considerable clinical, pathological, and genetic heterogeneity. Here we investigated the proteomic signatures of frontal and temporal cortex from brains with frontotemporal dementia due to GRN and MAPT mutations to identify the key cell types and molecular pathways in their pathophysiology. We compared patients with mutations in the GRN gene (n = 9) or with mutations in the MAPT gene (n = 13) with non-demented controls (n = 11). Using quantitative proteomic analysis on laser-dissected tissues we identified brain region-specific protein signatures for both genetic subtypes. Using published single cell RNA expression data resources we deduced the in

SUBMITTER: Miedema SSM 

PROVIDER: S-EPMC9261008 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature