The importance of mineralogical composition for the cytotoxic and pro-inflammatory effects of mineral dust.

ABSTRACT:

Background

Respirable mineral particles represent a potential health hazard in occupational settings and ambient air. Previous studies show that mineral particles may induce cytotoxicity and inflammatory reactions in vitro and in vivo and that the potency varies between samples of different composition. However, the reason for these differences is largely unknown and the impact of mineralogical composition on the biological effects of mineral dust remains to be determined.

Methods

We have assessed the cytotoxic and pro-inflammatory effects of ten mineral particle samples of different composition in human bronchial epithelial cells (HBEC3-KT) and THP-1-derived macrophages, as well as their membranolytic properties in erythrocytes. Moreover, the results were compiled with the

SUBMITTER: Grytting VS 

PROVIDER: S-EPMC9261052 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature