Development and validation of a multivariable prediction model of central venous catheter-tip colonization in a cohort of five randomized trials.

ABSTRACT:

Background

The majority of central venous catheters (CVC) removed in the ICU are not colonized, including when a catheter-related infection (CRI) is suspected. We developed and validated a predictive score to reduce unnecessary CVC removal.

Methods

We conducted a retrospective cohort study from five multicenter randomized controlled trials with systematic catheter-tip culture of consecutive CVCs. Colonization was defined as growth of ≥10³ colony-forming units per mL. Risk factors for colonization were identified in the training cohort (CATHEDIA and 3SITES trials; 3899 CVCs of which 575 (15%) were colonized) through multivariable analyses. After internal validation in 500 bootstrapped samples, the CVC-OUT score was computed by attaching points to the robust (> 50%

SUBMITTER: Iachkine J 

PROVIDER: S-EPMC9261073 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature