Associations between polygenic risk, negative symptoms, and functional connectome topology during a working memory task in early-onset schizophrenia.

ABSTRACT: Working memory (WM) deficit in schizophrenia is thought to arise from a widespread neural inefficiency. However, we do not know if this deficit results from the illness-related genetic risk and influence the symptom burden in various domains, especially in patients who have an early onset illness. We used graph theory to examine the topology of the functional connectome in 99 subjects (27 early-onset schizophrenia (EOS), 24 asymptomatic siblings, and 48 healthy subjects) during an n-back task, and calculated their polygenic risk score (PRS) for susceptibility to schizophrenia. Linear regression analysis was used to test associations of the PRS, clinical symptoms, altered connectomic properties, and WM accuracy in EOS. Indices of small-worldness and segregation were elevated in EOS during t

SUBMITTER: Deng M 

PROVIDER: S-EPMC9261080 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature