Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents.

ABSTRACT: Muscular strength, assessed by handgrip, is a risk indicator for psychiatric disorders, including psychosis. However, the biological mechanisms underlying this association remain unclear. Since advanced glycation end products (AGEs) play a key role in skeletal muscle underdevelopment and psychosis, we examined the role of AGEs in the longitudinal association between muscular strength and psychotic symptoms among adolescents. We first evaluated the direction of the relationship between handgrip strength and urine levels of pentosidine, a representative AGEs in a population-based birth cohort of 1,542 adolescents at ages 12 and 14. Then, we examined the role of AGEs in the longitudinal association between handgrip strength and thought problems (TP), as a psychotic symptom indicator, in a sub

SUBMITTER: Suzuki K 

PROVIDER: S-EPMC9261085 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature