Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients.

ABSTRACT: A better understanding of schizophrenia subtypes is necessary to stratify the patients according to clinical attributes. To explore the genomic architecture of schizophrenia symptomatology, we analyzed blood co-expression modules and their association with clinical data from patients in remission after a first episode of schizophrenia. In total, 91 participants of the 2EPS project were included. Gene expression was assessed using the Clariom S Human Array. Weighted-gene co-expression network analysis (WGCNA) was applied to identify modules of co-expressed genes and to test its correlation with global functioning, clinical symptomatology, and premorbid adjustment. Among the 25 modules identified, six modules were significantly correlated with clinical data. These modules could be clustered

SUBMITTER: Rodriguez N 

PROVIDER: S-EPMC9261105 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature