Age and CMV-Infection Jointly Affect the EBV-Specific CD8⁺ T-Cell Repertoire.

ABSTRACT: CD8⁺ T cells play an important role in protection against viral infections. With age, changes in the T-cell pool occur, leading to diminished responses against both new and recurring infections in older adults. This is thought to be due to a decrease in both T-cell numbers and T-cell receptor (TCR) diversity. Latent infection with cytomegalovirus (CMV) is assumed to contribute to this age-associated decline of the immune system. The observation that the level of TCR diversity in the total memory T-cell pool stays relatively stable during aging is remarkable in light of the constant input of new antigen-specific memory T cells. What happens with the diversity of the individual antigen-specific T-cell repertoires in the memory pool remains largely unknown. Here we studied the effe

SUBMITTER: Lanfermeijer J 

PROVIDER: S-EPMC9261403 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature