Genetically selected alcohol-preferring msP rats to study alcohol use disorder: Anything lost in translation?

ABSTRACT: For several decades, genetically selected alcohol-preferring rats have been successfully used to mimic and study alcohol use disorders (AUD). These rat lines have been instrumental in advancing our understanding of the neurobiology of alcoholism and enabling pharmacological studies to evaluate drug efficacy on alcohol drinking and relapse. Moreover, the results of these studies have identified genetic variables that are linked to AUD vulnerability. This is an up-to-date review that focuses on genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. To support the translational relevance of the findings that are obtained from msP rats and highlight important similarities to AUD patients, we also discuss the results of recent brain imaging studies. Finally, to demonstrate the

SUBMITTER: Borruto AM 

PROVIDER: S-EPMC9261425 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature