Reduced Bordetella pertussis-specific CD4⁺ T-Cell Responses at Older Age.

ABSTRACT: Pertussis, a human-specific respiratory infectious disease caused by the Gram-negative bacterium Bordetella pertussis (Bp), remains endemic with epidemic years despite high vaccination coverage. Whereas pertussis vaccines and natural infection with Bp confer immune protection, the duration of protection varies and is not lifelong. Recent evidence indicates a considerable underestimation of the pertussis burden among older adults. Whereas the impact of increasing age on Bp-specific humoral immunity has been demonstrated, little is known on immunosenescence of CD4⁺ T-cell responses in the context of Bp. Here, we aimed to address whether increasing age impacts responsiveness of the Bp-specific CD4⁺ T-cells in the memory pool following a clinically symptomatic pert

SUBMITTER: Lambert EE 

PROVIDER: S-EPMC9261443 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature