Heterogeneity in statin responses explained by variation in the human gut microbiome.

ABSTRACT:

Background

Statins remain one of the most prescribed medications worldwide. While effective in decreasing atherosclerotic cardiovascular disease risk, statin use is associated with adverse effects for a subset of patients, including disrupted metabolic control and increased risk of type 2 diabetes.

Methods

We investigated the potential role of the gut microbiome in modifying patient responses to statin therapy across two independent cohorts (discovery n = 1,848, validation n = 991). Microbiome composition was assessed in these cohorts using stool 16S rRNA amplicon and shotgun metagenomic sequencing, respectively. Microbiome associations with markers of statin on-target and adverse effects were tested via a covariate-adjusted interaction analysis framework, utilizing blood me

SUBMITTER: Wilmanski T 

PROVIDER: S-EPMC9261472 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature