Curcumin effect on Acanthamoeba triangularis encystation under nutrient starvation.

ABSTRACT:

Background

Curcumin is an active compound derived from turmeric, Curcuma longa, and is known for its benefits to human health. The amoebicidal activity of curcumin against Acanthamoeba triangularis was recently discovered. However, a physiological change of intracellular pathways related to A. triangularis encystation mechanism, including autophagy in the surviving amoeba after curcumin treatment, has never been reported. This study aims to investigate the effect of curcumin on the survival of A. triangularis under nutrient starvation and nutrient-rich condition, as well as to evaluate the A. triangularis encystation and a physiological change of Acanthamoeba autophagy at the mRNA level.

Methods

In this study, A. triangularis

SUBMITTER: Boonhok R 

PROVIDER: S-EPMC9261923 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature