Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene-environment correlations.

ABSTRACT: Familial risk for depression is associated with youth exposure to self-generated dependent stressful life events and independent events that are out of youth's control. Familial risk includes both genetic and environmental influences, raising the question of whether genetic influences, specifically, are associated with youth exposure to both dependent and independent stressful life events. To address this question, this study examined the relation between a genome-wide association study (GWAS)-derived depression-based polygenic risk score (DEP-PRS) and youth experiences of dependent and independent stress. Participants were 180 youth (ages 8 to 14, 52.2% female) of European ancestry and their biological mothers recruited based on the presence versus absence of a history of major depressive

SUBMITTER: Feurer C 

PROVIDER: S-EPMC9262038 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature