Glymphatic System in Ocular Diseases: Evaluation of MRI Findings.

ABSTRACT:

Background and purpose

There is growing evidence of leakage of gadolinium in an impaired blood-retina barrier. We investigated gadolinium enhancement in different eye compartments and correlated the enhancement with specific ophthalmologic diseases.

Materials and methods

In a prospective clinical study (ClinicalTrials.gov Identifier: NCT05035251), 95 patients (63 with and 32 without ophthalmologic disease) were examined before and after gadolinium administration (20 and 120 minutes) with heavily T2-weighted FLAIR. The cohort was divided according to the location of pathology into anterior and posterior eye compartment groups. Relative signal intensity increase in the anterior eye chamber, vitreous body with retina, optic nerve sheath, and the Meckel cave was analyzed and cor

SUBMITTER: Manava P 

PROVIDER: S-EPMC9262072 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature