In silico analyses of leptin and leptin receptor of spotted snakehead Channa punctata.

ABSTRACT: The present study, in addition to molecular characterization of leptin (lepa) and its receptor (lepr) of spotted snakehead Channa punctata, is focussed on physicochemical, structural, evolutionary and selection pressure analyses which are poorly elucidated in teleosts in spite of that existence of these genes is well reported in several fish species. The putative full-length Lep and Lepr of C. punctata showed conserved structural and functional domains, especially the residues responsible for structural integrity and signal transduction. Conversely, residues predicted essential for Lep-Lepr interaction displayed divergence between teleosts and tetrapods. Impact of substitutions/deletions predicted using protein variation effect analyser tool highlighted species specificity in ligand-recept

SUBMITTER: Bakshi A 

PROVIDER: S-EPMC9262212 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature