Dual Antibody-Conjugated Amyloid Nanorods to Promote Selective Cell-Cell Interactions.

ABSTRACT: Grafting biomolecules on nanostructures' surfaces is an increasingly used strategy to target pathogenic cells, with both diagnostic and therapeutic applications. However, nanomaterials monofunctionalized by conjugating a single type of ligand find limited uses in pathologies/therapies that require two or more targets/receptors to be targeted and/or activated with a single molecular entity simultaneously. Therefore, multivalent nanomaterials for dual- or multitargeting are attracting significant interest. This study provides a proof of concept of such nanostructures. We have recently developed a modular methodology that allows obtaining amyloid-based materials decorated with active globular domains. Here, this approach is exploited to generate functional amyloid fibrils displaying antibody

SUBMITTER: Wang W 

PROVIDER: S-EPMC9262253 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature