Anti-liver fibrosis effects of the total flavonoids of litchi semen on CCl₄-induced liver fibrosis in rats associated with the upregulation of retinol metabolism.

ABSTRACT:

Context

The litchi semen are traditional medications for treating liver fibrosis (LF) in China. The mechanism remains unclear.

Objective

This study investigates the anti-liver fibrotic mechanism of the total flavonoids of litchi semen (TFL).

Materials and methods

Sprague-Dawley rats with carbon tetrachloride-induced LF were treated with TFL (50 and 100 mg/kg) for 4 weeks. The anti-liver fibrotic effects of TFL were evaluated and the underlying mechanisms were investigated via histopathological analysis, proteomic analysis and molecular biology technology.

Results

Significant anti-LF effects were observed in the high-TFL-dose group (TFL-H, p < 0.05). Five hundred and eighty-five and 95 differentially expressed proteins (DEPs) were identified in the LF rat

SUBMITTER: Yan J 

PROVIDER: S-EPMC9262366 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature