Low Expression of miR-491-3p Is Correlated with Lymph Node Metastasis in Gastric Cancer.

ABSTRACT:

Objective

MiR-491-3p, as a tumor suppressor miRNA, was found decreased in many solid tissues. In this study, we aim to investigate miR-491-3p expression in gastric cancer with or without lymph node metastasis (LNM).

Methods

GSE173215 dataset from Gene Expression Omnibus (GEO) was used to measure miRNA expression from tissue samples of gastric cancer patients. Moreover, gastric tumor tissues (non-LNM: n = 78; LNM: n = 68) were obtained to detect the miR-491-3p expression. Receiver operating characteristic (ROC) curve and Kaplan-Meier (KM) survival analysis, as well as Cox regression analysis, were performed to reveal the role of miR-491-3p in diagnosis and prognosis of gastric cancer.

Results

According to GSE173215 datasets (t = -11.25, adjust P

SUBMITTER: Yu H 

PROVIDER: S-EPMC9262502 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature