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ABSTRACT:
SUBMITTER: Ojha D
PROVIDER: S-EPMC9262582 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Ojha Debika D Jaszczur Malgorzata M MM Sikand Adhirath A McDonald John P JP Robinson Andrew A van Oijen Antoine M AM Mak Chi H CH Pinaud Fabien F Cox Michael M MM Woodgate Roger R Goodman Myron F MF
Nucleic acids research 20220701 12
Homologs of the mutagenic Escherichia coli DNA polymerase V (pol V) are encoded by numerous pathogens and mobile elements. We have used Rum pol (RumA'2B), from the integrative conjugative element (ICE), R391, as a model mobile element-encoded polymerase (MEPol). The highly mutagenic Rum pol is transferred horizontally into a variety of recipient cells, including many pathogens. Moving between species, it is unclear if Rum pol can function on its own or requires activation by host factors. Here, ...[more]