Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication.

ABSTRACT: Antiviral innate immunity represents the first defense against invading viruses and is key to control viral infections, including SARS-CoV-2. Body temperature is an omnipresent variable but was neglected when addressing host defense mechanisms and susceptibility to SARS-CoV-2 infection. Here, we show that increasing temperature in a 1.5°C window, between 36.5 and 38°C, strongly increases the expression of genes in two branches of antiviral immunity, nitric oxide production and type I interferon response. We show that alternative splicing coupled to nonsense-mediated decay decreases STAT2 expression in colder conditions and suggest that increased STAT2 expression at elevated temperature induces the expression of diverse antiviral genes and SARS-CoV-2 restriction factors. This cascade is act

SUBMITTER: Los B 

PROVIDER: S-EPMC9262603 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature