The transcription factor network of E. coli steers global responses to shifts in RNAP concentration.

ABSTRACT: The robustness and sensitivity of gene networks to environmental changes is critical for cell survival. How gene networks produce specific, chronologically ordered responses to genome-wide perturbations, while robustly maintaining homeostasis, remains an open question. We analysed if short- and mid-term genome-wide responses to shifts in RNA polymerase (RNAP) concentration are influenced by the known topology and logic of the transcription factor network (TFN) of Escherichia coli. We found that, at the gene cohort level, the magnitude of the single-gene, mid-term transcriptional responses to changes in RNAP concentration can be explained by the absolute difference between the gene's numbers of activating and repressing input transcription factors (TFs). Interestingly, this difference is st

SUBMITTER: L B Almeida B 

PROVIDER: S-EPMC9262627 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature