Interplay of Vitamin D and CYP3A4 Polymorphisms in Endocrine Disorders and Cancer.

ABSTRACT: Vitamin D has received considerable optimistic attention as a potentially important factor in many pathological states over the past few decades. However, the proportion of the active form of vitamin D metabolites responsible for biological activity is highly questionable in disease states due to flexible alterations in the enzymes responsible for their metabolism. For instance, CYP3A4 plays a crucial role in the biotransformation of vitamin D and other drug substances. Food-drug and/or drug-drug interactions, the disease state, genetic polymorphism, age, sex, diet, and environmental factors all influence CYP3A4 activity. Genetic polymorphisms in CYP450-encoding genes have received considerable attention in the past few decades due to their extensive impact on the pharmacokinetic and dynam

SUBMITTER: Kasarla SS 

PROVIDER: S-EPMC9262690 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature