Telomerase positive CTCs with PSMA high expression associated with prostate cancer metastasis.

ABSTRACT:

Background

Whether circulating tumor cells (CTCs) with prostate-specific membrane antigen (PSMA) high expression was related to the metastatic progress in prostate cancer (PCa) remains explored. This study aimed to provide evidence to elucidate this relationship via the telomerase reverse transcriptase (TERT)-based CTC detection method.

Methods

A total of 71 patients were enrolled and divided into the local PCa group (n=44) and metastatic PCa group (n=27). TERT-based CTC detection (TBCD) was used to detect CTCs. CTCs single-cell sequencing data were analyzed using gene ontology (GO) functional classification and enrichment.

Results

The mean 'TERT⁺ CTCs' number was 6.11±9.63 in the metastatic group and 4.09±3.41 in the local group. GO enrichment analysis for

SUBMITTER: Yang Z 

PROVIDER: S-EPMC9262742 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature