Shenjing Guben Wan promotes sperm development by increasing the activity of seminiferous epithelium Sertoli cells.

ABSTRACT:

Background

Infertility is an important social problem. Asthenozoospermia (AZS) is a common pathological cause of male infertility, but its pathogenesis is unclear. Shenjing Guben Wan (SJGBW), a traditional Chinese medicine, has shown remarkable effects during the clinical treatment of oligozoospermia or AZS.

Methods

In this study, clinical evaluations were carried out on 184 AZS patients receiving SJGBW treatment, including sperm count, sperm quality, and pregnancy rate. Also, ornidazole was used to build an AZS mouse model, and SJGBW treatment was administered. The sperm quantity and fertility of mice in different groups were evaluated; a cholecystokinin octapeptide-8 (CCK-8) experiment was carried out to test the activity of seminiferous epithelium Sertoli cells, and immun

SUBMITTER: Liu H 

PROVIDER: S-EPMC9262746 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature