Coordination of inflammatory responses in children with perinatally acquired HIV infection.

ABSTRACT:

Objective

We investigated dynamics of inflammatory biomarkers in children with perinatally acquired HIV (PHIV) who started antiretrovirals at age less than 3 years and achieved sustained virologic control (HIV plasma RNA <400 copies/ml).

Design

This was a retrospective analysis of inflammatory biomarkers in children enrolled in a randomized trial of early (<3 years of age) PI-based versus NNRTI-based regimens (P1060), who achieved sustained virologic control and participated in a neurodevelopmental follow-up study (P1104s) between ages 5 and 11 years.

Methods

We measured 20 inflammatory biomarkers using ELISA or chemiluminescence at onset of sustained virologic control (Tc) and at P1104s entry (Te).

Results

The 213 participants had median ages of 1.2, 1.9, and

SUBMITTER: Weinberg A 

PROVIDER: S-EPMC9262767 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature