Modern developments in germline pharmacogenomics for oncology prescribing.

ABSTRACT: The integration of genomic data into personalized treatment planning has revolutionized oncology care. Despite this, patients with cancer remain vulnerable to high rates of adverse drug events and medication inefficacy, affecting prognosis and quality of life. Pharmacogenomics is a field seeking to identify germline genetic variants that contribute to an individual's unique drug response. Although there is widespread integration of genomic information in oncology, somatic platforms, rather than germline biomarkers, have dominated the attention of cancer providers. Patients with cancer potentially stand to benefit from improved integration of both somatic and germline genomic information, especially because the latter may complement treatment planning by informing toxicity risk for drugs wi

SUBMITTER: Reizine NM 

PROVIDER: S-EPMC9262778 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature