Phenotypic and functional alterations of peritoneal macrophages in lupus-prone mice.

ABSTRACT:

Background

Several studies have demonstrated the contribution of innate immune cells, including macrophages, in promoting systemic lupus erythematosus (SLE). Macrophages, one of the most abundant cell populations in the peritoneal cavity, are considered multifunctional cells with phenotypic plasticity. However, the functional properties of peritoneal macrophages in steady-state and during the progression of SLE remain poorly defined.

Methods and results

Using the [NZB × NZW]F1 (BWF1) murine model of SLE, we analyzed the phenotype and function of peritoneal macrophages during the disease's onset. We found a higher frequency of peritoneal macrophages and B1a cells in BWF1-diseased mice than age-matched controls. Additionally, macrophages from diseased animals expressed lower l

SUBMITTER: Tejon G 

PROVIDER: S-EPMC9262788 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature