Ontology highlight
ABSTRACT:
SUBMITTER: Ng D
PROVIDER: S-EPMC9262973 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Ng Deanna D Ali Aiman A Lee Kiera K Eymael Denise D Abe Kento K Luu Shelly S Kazazian Karineh K Lu Yi Qing YQ Brar Savtaj S Conner James J Magalhaes Marco M Swallow Carol J CJ
Scientific reports 20220707 1
Gastric adenocarcinoma, commonly known as stomach cancer, has a predilection for metastasis to the peritoneum, which portends limited survival. The peritoneal metastatic cascade remains poorly understood, and existing models fail to recapitulate key elements of the interaction between cancer cells and the peritoneal layer. To explore the underlying cellular and molecular mechanisms of peritoneal metastasis, we developed an ex vivo human peritoneal explant model. Fresh peritoneal tissue samples w ...[more]