T2 relaxation time for the early prediction of treatment response to chemoradiation in locally advanced rectal cancer.

ABSTRACT:

Objectives

Poor responders to chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC) can still have a good prognosis if the treatment strategy is changed in time. However, no reliable predictor of early-treatment response has been identified. The purpose of this study was to investigate the role of T2 relaxation time in magnetic resonance imaging (MRI) for the early prediction of a pathological response to CRT in LARC.

Methods

A total of 123 MRIs were performed on 41 LARC patients immediately before, during, and after CRT. The corresponding tumor volume, T2 relaxation time, and apparent diffusion coefficient (ADC) values at different scan time points were obtained. The Mann-Whitney U test was used to compare the T2 relaxation time between pathological good respond

SUBMITTER: Ge Y 

PROVIDER: S-EPMC9263013 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature