Assessment of the TGFB1 gene expression and methylation status of the promoter region in patients with colorectal cancer.

ABSTRACT: The aim of this study was to evaluate the expression of the TGFB1 gene encoding the TGF-β1 cytokine in 64 patients, and then to compare it with clinico-pathological features. The study also investigated whether the regulation of the gene expression is caused by methylation of the promoter region between - 235 and + 22 nucleotide from the start of transcription. The dependence of the relative level of the TGFB1 gene expression on the clinical advancement according to the TNM classifications was shown. Additionally, the individual grades of the T and M features of the TNM classification differed in the relative transcript levels of the TGFB1 gene. Moreover, the higher relative expression level of the studied gene was associated with a lack of vascular invasion by cancer cells and presence of

SUBMITTER: Wodzinski D 

PROVIDER: S-EPMC9263105 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature