Development of Human Cell-Based In Vitro Infection Models to Determine the Intracellular Survival of Mycobacterium avium.

ABSTRACT: The Mycobacterium avium (Mav) complex accounts for more than 80% of all pulmonary diseases caused by non-tuberculous mycobacteria (NTM) infections, which have an alarming increase in prevalence and vary in different regions, currently reaching 0.3-9.8 per 100,000 individuals. Poor clinical outcomes, as a result of increasing microbial drug resistance and low treatment adherence due to drug-toxicities, emphasize the need for more effective treatments. Identification of more effective treatments, however, appears to be difficult, which may be due to the intracellular life of NTM and concomitant altered drug sensitivity that is not taken into account using traditional drug susceptibility testing screenings. We therefore developed human cell-based in vitro Mav infection mo

SUBMITTER: Kilinc G 

PROVIDER: S-EPMC9263196 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature