Plasma Biomarkers as Risk Factors for Incident CKD.

ABSTRACT:

Introduction

Earlier identification of individuals at high risk of chronic kidney disease (CKD) may facilitate improved risk factor mitigation.

Methods

We evaluated the association of novel plasma biomarkers with incident CKD using a case-cohort design in participants without diabetes and with baseline estimated glomerular filtration rate (eGFR) ≥ 60 ml/min per 1.73 m² in the Multi-Ethnic Study of Atherosclerosis (MESA) and Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohorts. Incident CKD was defined as development of eGFR < 60 ml/min per 1.73 m² and ≥40% decline in eGFR from baseline. We measured plasma markers of inflammation/fibrosis-soluble tumor necrosis factor receptors (TNFRs) 1 and 2 (TNFR-1 and TNFR-2), monocyte chemotacti

SUBMITTER: Sarnak MJ 

PROVIDER: S-EPMC9263237 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature