The Clinical and Pathologic Phenotype of Antibody-Mediated Vascular Rejection Diagnosed Using Arterial C4d Immunoperoxidase.

ABSTRACT:

Introduction

The diagnosis of antibody-mediated vascular rejection (AM-VR) should be reliable and accurate. We hypothesized that arterial C4d (C4d_art) immunoperoxidase deposition represents endothelial interaction with antibody.

Methods

From 3309 consecutive, kidney transplant biopsies from a single center, 100 vascular rejection (VR) cases were compared against rejection without arteritis (n = 540) and normal controls (n = 1108). The clinical utility of C4d_art for diagnosis and classification of AM-VR was evaluated against an independent reference test.

Results

C4d_art occurred in 20.4% of acute, 11.0% of subclinical, and 46% of VR episodes. Semiquantitative C4d_art score significantly correlated with immunodomi

SUBMITTER: Nankivell BJ 

PROVIDER: S-EPMC9263238 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature