Glomerular C4d Immunoperoxidase in Chronic Antibody-Mediated Rejection and Transplant Glomerulopathy.

ABSTRACT:

Introduction

The diagnosis of late antibody-mediated rejection (AMR) is compromised by frequent absence of C4d in peritubular capillaries (C4d_ptc), termed "C4d-negative" AMR. We hypothesized that glomerular capillary C4d (C4d_glom) reflected endothelial interaction with antibody and could improve immunologic classification of transplant glomerulopathy (TG).

Methods

We evaluated C4d using immunoperoxidase in 3524 consecutive, kidney transplant biopsies from a single center.

Results

C4d_glom was detected in 16.5% and C4d_ptc in 9.9% of biopsies. C4d_glom occurred in 60.3% of TG (n = 174) and was absent in normal glomeruli. Epidemiologic risk factors for C4d_glom were younger, female, living-donor recipi

SUBMITTER: Nankivell BJ 

PROVIDER: S-EPMC9263257 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature