Modeling Neurodegenerative Diseases Using In Vitro Compartmentalized Microfluidic Devices.

ABSTRACT: The human brain is a complex organ composed of many different types of cells interconnected to create an organized system able to efficiently process information. Dysregulation of this delicately balanced system can lead to the development of neurological disorders, such as neurodegenerative diseases (NDD). To investigate the functionality of human brain physiology and pathophysiology, the scientific community has been generated various research models, from genetically modified animals to two- and three-dimensional cell culture for several decades. These models have, however, certain limitations that impede the precise study of pathophysiological features of neurodegeneration, thus hindering therapeutical research and drug development. Compartmentalized microfluidic devices provide in

SUBMITTER: Miny L 

PROVIDER: S-EPMC9263267 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature