Leukoaraiosis Distribution and Cerebral Collaterals: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background and objective

Microvascular failure might result in the collapse of cerebral collaterals. However, controversy remains regarding the role of leukoaraiosis (LA) in collateral recruitment. We, therefore, performed a systematic review and meta-analysis of the association between LA and cerebral collaterals.

Methods

Ovid Medline, PubMed, Embase, Web of Science, and three Chinese databases were searched from inception to August 2021. Two types of cerebral collaterals, including Circle of Willis (CoW) and leptomeningeal collaterals (LC), were investigated separately. Random effect models were used to calculate the pooled odds ratio (OR). Meta-regression and subgroup analyses were performed to explore the potential sources of heterogeneity.

Results

From 14 studies

SUBMITTER: Xu M 

PROVIDER: S-EPMC9263359 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature